AEMCA Practice Exam

What is the function of 2,3 DPG in red blood cells?

1. Enhances oxygen binding to hemoglobin

2. Aids in carbon dioxide transport

3. Created by RBC from glycolysis to regulate hemoglobin affinity

4. Acts as a buffer in blood pH regulation

The correct answer is: Created by RBC from glycolysis to regulate hemoglobin affinity

The function of 2,3-Diphosphoglycerate (2,3-DPG) within red blood cells is crucial for regulating the affinity of hemoglobin for oxygen. Specifically, 2,3-DPG is produced as a byproduct of the glycolytic pathway in red blood cells and significantly influences how hemoglobin binds and releases oxygen. When 2,3-DPG binds to hemoglobin, it lowers hemoglobin's affinity for oxygen. This effect facilitates the release of oxygen to tissues that are utilizing it during metabolic processes, especially when oxygen demand is high, such as in exercising muscles. The production of 2,3-DPG is increased in situations where there is a need for enhanced oxygen delivery, such as in chronic hypoxia or at high altitudes. Hence, the ability of red blood cells to generate 2,3-DPG allows for a tailored response to varying oxygen needs within the body, making it an essential component in the oxygen transport system. This mechanism of action underscores the importance of 2,3-DPG in ensuring that tissues receive an adequate supply of oxygen based on their metabolic activity, aligning hemoglobin's oxygen affinity with the physiological demands of the organism.