AEMCA Practice Exam

What is the mechanism of action of ibuprofen?

1. Inhibiting COX and prostaglandin synthesis

2. Increasing the rate of hemoglobin synthesis

3. Increasing blood circulation

4. Enhancing neurotransmitter function

The correct answer is: Inhibiting COX and prostaglandin synthesis

The mechanism of action of ibuprofen is primarily based on its ability to inhibit the cyclooxygenase (COX) enzymes, which are responsible for the conversion of arachidonic acid into prostaglandins. Prostaglandins are compounds that play a key role in the inflammatory response, and they are also involved in processes like pain perception and fever regulation. By inhibiting COX enzymes, ibuprofen effectively reduces the synthesis of these inflammatory mediators, leading to decreased inflammation, pain relief, and a reduction in fever. This makes ibuprofen a non-steroidal anti-inflammatory drug (NSAID) that is widely used for its analgesic and anti-inflammatory properties. Understanding this mechanism is crucial for effective pain management and recognizing the therapeutic applications of ibuprofen in various clinical scenarios.