AEMCA Practice Exam

Where is Angiotensin-Converting Enzyme (ACE) produced?

1. Kidneys

2. Liver

3. Lungs

4. Adrenal cortex

The correct answer is: Lungs

Angiotensin-Converting Enzyme (ACE) is primarily produced in the lungs. This enzyme plays a crucial role in the renin-angiotensin system, which is essential for regulating blood pressure and fluid balance in the body. ACE catalyzes the conversion of angiotensin I, which is an inactive peptide, into angiotensin II, a potent vasoconstrictor that helps to increase blood pressure. While the kidneys produce renin, which initiates the process, and the liver produces angiotensinogen (the precursor to angiotensin I), it is the lungs that are specifically noted for the production and activity of ACE. The presence of ACE in the lungs allows for efficient conversion of angiotensin I as blood flows through the pulmonary circulation. Understanding the location and function of ACE is significant in the context of cardiovascular health and the pharmacological targets for managing conditions such as hypertension, where ACE inhibitors are commonly used.