AEMCA Practice Exam

Which factor is associated with the stimulation of renin release in the kidneys?

1. Increased sodium chloride transport at the macula densa

2. Reduction of sodium chloride transport at the thick ascending limb

3. Increased pressure in the afferent arterioles

4. Increased potassium levels in the blood

The correct answer is: Reduction of sodium chloride transport at the thick ascending limb

The stimulation of renin release in the kidneys is closely tied to sodium chloride levels detected by specialized cells called macula densa, which are part of the juxtaglomerular apparatus. When the transport of sodium chloride decreases at the macula densa, it signals that there might be a drop in blood volume or blood pressure, prompting the juxtaglomerular cells to release renin. Renin then plays a crucial role in the renin-angiotensin-aldosterone system, which helps to regulate blood pressure and fluid balance. The correct option highlights the importance of sodium chloride transport levels, reflecting how the kidneys respond to perceived changes in fluid status. When sodium chloride transport is reduced, it indicates that the body may be retaining water or experiencing hypotension, triggering the release of renin to ultimately help restore proper hemodynamics. Conversely, increased sodium chloride transport or increased pressure in the afferent arterioles would lead to a different physiological response. Increased sodium chloride levels or adequate pressure typically inhibit renin release, reflecting adequate perfusion and fluid status. High potassium levels can influence aldosterone secretion but are not directly involved in the mechanism of renin release. Thus, the choice of reduced sodium chloride transport at the mac