AEMCA Practice Exam

Which symptoms might indicate an overdose on cholinergics?

1. Mitosis, tachycardia, and high blood pressure

2. Mitosis, bronchial secretions, weakness, and seizures

3. Lethargy, decreased urination, and tremors

4. Apathy, shortness of breath, and cough

The correct answer is: Mitosis, bronchial secretions, weakness, and seizures

Choosing the option that includes mitosis, bronchial secretions, weakness, and seizures aligns well with the symptoms typically associated with an overdose of cholinergic agents. Cholinergic drugs work by enhancing the activity of the neurotransmitter acetylcholine, which can lead to overstimulation of the parasympathetic nervous system when taken in excess. Miosis, or constricted pupils, is a classic sign of cholinergic overdose as the overactivity of acetylcholine receptor stimulation in the eye leads to pupil constriction. Increased bronchial secretions occur due to excessive stimulation of the muscarinic receptors, which can cause respiratory distress if not managed. Weakness is also a common consequence, as cholinergic toxicity can affect neuromuscular junction function and muscle control. Lastly, seizures may occur due to the central effects of excessive acetylcholine, which can lead to excitatory effects on the central nervous system. The other options presented do not reflect the characteristically recognized symptoms of cholinergic overdose. For example, symptoms like tachycardia and hypertension are more aligned with anticholinergic effects rather than cholinergic overdose. Therefore, option B accurately highlights symptoms consistent with cholinergic toxicity and provides a better understanding of the